What is Trimethylglycine? Benefits, Dosage, and Risks of TMG
Trimethylglycine, also known as TMG or betaine, is an essential compound produced naturally by the human body. It can also be taken as a TMG supplement and occurs in certain foods....
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PQQ Is More Than an Antioxidant: A Vitamin-like Accessory Factor Important in Health and Disease Prevention
Karen R Jonscher 1, Winyoo Chowanadisai 2, Robert B Rucker 3,* Editor: Piergiorgio Messa PMCID: PMC8533503 PMID: 34680074 Abstract Pyrroloquinoline quinone (PQQ) is associated with biological processes such as mitochondriogenesis, reproduction, growth, and aging. In addition, PQQ attenuates...
PQQ to reduce fat accumulation and ameliorate obesity progression
Nur Syafiqah Mohamad Ishak†Kazuto Ikemoto*† Niigata Research Laboratory, Mitsubishi Gas Chemical Company, Inc., Niigata, Japan Obesity is a major health concern worldwide, and its prevalence continues to increase in...
Nicotinamide Riboside—The Current State of Research and Therapeutic Uses
Mario Mehmel 1, Nina Jovanović 2, Urs Spitz 3,* Abstract Nicotinamide riboside (NR) has recently become one of the most studied nicotinamide adenine dinucleotide (NAD+) precursors, due to its numerous potential health benefits mediated...
Nicotinamide riboside improves muscle mitochondrial biogenesis, satellite cell differentiation, and gut microbiota in a twin study
Helena A. K. Lapatto https://orcid.org/0000-0002-6655-4415, Minna Kuusela https://orcid.org/0000-0001-7847-5629, Aino Heikkinen https://orcid.org/0000-0001-5770-6475, Maheswary Muniandy https://orcid.org/0000-0001-7624-7948, [...] , and Eija Pirinen https://orcid.org/0000-0002-9821-2516 +22 authors Authors Info & Abstract Nicotinamide adenine dinucleotide (NAD+) precursor nicotinamide riboside (NR) has emerged as a promising compound to improve obesity-associated mitochondrial dysfunction and metabolic syndrome in...
The Clinical Effects of Nicotinamide Riboside on Inflammatory Parameters
Jun Kwon 1, Rebecca Idoine 1, Yusrah Ishtiaq 1, Yasmeen Nkrumah-Elie 1, Mona Rosene 1, Andrew Shao 1 Objectives: Nicotinamide adenine dinucleotide (NAD+) coenzymes are the central regulators of cellular metabolism. While the NAD + system is dysregulated by metabolic stress and age-related conditions, nicotinamide riboside (NR)...
Nicotinamide riboside for peripheral artery disease: the NICE randomized clinical trial
People with lower extremity peripheral artery disease (PAD) have increased oxidative stress, impaired mitochondrial activity, and poor walking performance. NAD+ reduces oxidative stress and is an essential cofactor for mitochondrial respiration....
The therapeutic perspective of NAD+ precursors in age-related diseases
Highlights • NAD+ levels decline with aging and various nutrient stresses. • Reduced NAD+ levels cause aging and aging-associated disease. • Administration of NAD+ precursors exhibit beneficial effects against aging in animal models...
First human clinical trial for nicotinamide riboside
First human clinical trial for nicotinamide riboside Date: Monday, October 10, 2016 Vitamin safely boosts levels of important cell metabolite linked to multiple health benefits In the first controlled clinical trial...
The Role of NAD+ in Regenerative Medicine
The Role of NAD+ in Regenerative Medicine Nichola J Conlon 1,2,✉ Author information Article notes Copyright and License information PMCID: PMC9512238 PMID: 36170435 Summary: The understanding of the molecular and cellular basis of...