What is Trimethylglycine? Benefits, Dosage, and Risks of TMG
Trimethylglycine, also known as TMG or betaine, is an essential compound produced naturally by the human body. It can also be taken as a TMG supplement and occurs in certain foods....
Backed by Science
NAD+ is a powerhouse molecule that's essential to cellular health and longevity
- Energy Production: NAD⁺ is crucial for converting nutrients into cellular energy (ATP) in the mitochondria.
- DNA Repair: It activates enzymes like PARPs, which help repair damaged DNA.
- Cell Survival: NAD⁺ supports sirtuins — proteins that regulate aging, inflammation, and metabolism.
- Metabolic Regulation: It helps regulate glucose, fatty acid, and amino acid metabolism.
NAD+ levels drop 50%+ from ages 30-50
NAD+ is the closest we've gotten to a fountain of youth"
-David Sinclair,Harvard Medical School
12 Hallmarks of Aging
Our Ingredients
Carefully formulated ingredients by top-tier scientists from Oxford, Cornell, & Yale
NAD+ (NR)
A coenzyme found in all living cells that plays a crucial role in energy production, DNA repair, improving muscle function, anti-aging and cellular health.
Rhodiola Rosea Root
An adaptogen used to help the body manage stress. It's been shown to improve mental clarity, mood, and physical endurance
Theacrine + PQQ + TMG
Theacrine provides a sustained energy release with no crash. PQQ supports energy production by enhancing mitochondrial function. TMG detoxes and supports DNA repair. It has also shown to benefit cardiovasuclar health and cognitive function
Why NR? (Nicotinamide Riboside)
NR is a pre-cursor to NAD+, which means that it converts into NAD+ more easily.
- NR is smaller and more stable, allowing it to enter cells directly and convert efficiently into NAD+
- Once inside the cell, NR is converted into NAD+ via a two-step process using enzymes already present in the body
- NAD+ itself has poor bioavailability when taken orally because it's rapidly broken down in the GI tract before it can reach the bloodstream.
Blog
PQQ Is More Than an Antioxidant: A Vitamin-like Accessory Factor Important in Health and Disease Prevention
Karen R Jonscher 1, Winyoo Chowanadisai 2, Robert B Rucker 3,* Editor: Piergiorgio Messa PMCID: PMC8533503 PMID: 34680074 Abstract Pyrroloquinoline quinone (PQQ) is associated with biological processes such as mitochondriogenesis, reproduction, growth, and aging. In addition, PQQ attenuates...
PQQ to reduce fat accumulation and ameliorate obesity progression
Nur Syafiqah Mohamad Ishak†Kazuto Ikemoto*† Niigata Research Laboratory, Mitsubishi Gas Chemical Company, Inc., Niigata, Japan Obesity is a major health concern worldwide, and its prevalence continues to increase in...
Nicotinamide Riboside—The Current State of Research and Therapeutic Uses
Mario Mehmel 1, Nina Jovanović 2, Urs Spitz 3,* Abstract Nicotinamide riboside (NR) has recently become one of the most studied nicotinamide adenine dinucleotide (NAD+) precursors, due to its numerous potential health benefits mediated...
Nicotinamide riboside improves muscle mitochondrial biogenesis, satellite cell differentiation, and gut microbiota in a twin study
Helena A. K. Lapatto https://orcid.org/0000-0002-6655-4415, Minna Kuusela https://orcid.org/0000-0001-7847-5629, Aino Heikkinen https://orcid.org/0000-0001-5770-6475, Maheswary Muniandy https://orcid.org/0000-0001-7624-7948, [...] , and Eija Pirinen https://orcid.org/0000-0002-9821-2516 +22 authors Authors Info & Abstract Nicotinamide adenine dinucleotide (NAD+) precursor nicotinamide riboside (NR) has emerged as a promising compound to improve obesity-associated mitochondrial dysfunction and metabolic syndrome in...
The Clinical Effects of Nicotinamide Riboside on Inflammatory Parameters
Jun Kwon 1, Rebecca Idoine 1, Yusrah Ishtiaq 1, Yasmeen Nkrumah-Elie 1, Mona Rosene 1, Andrew Shao 1 Objectives: Nicotinamide adenine dinucleotide (NAD+) coenzymes are the central regulators of cellular metabolism. While the NAD + system is dysregulated by metabolic stress and age-related conditions, nicotinamide riboside (NR)...
Nicotinamide riboside for peripheral artery disease: the NICE randomized clinical trial
People with lower extremity peripheral artery disease (PAD) have increased oxidative stress, impaired mitochondrial activity, and poor walking performance. NAD+ reduces oxidative stress and is an essential cofactor for mitochondrial respiration....
The therapeutic perspective of NAD+ precursors in age-related diseases
Highlights • NAD+ levels decline with aging and various nutrient stresses. • Reduced NAD+ levels cause aging and aging-associated disease. • Administration of NAD+ precursors exhibit beneficial effects against aging in animal models...
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